The 5 HT2A receptor is a receptor in the brain that binds to serotonin. It is a G Protein-Coupled Receptor, or GPCR, meaning that when the receptor binds to its target molecule, a G-protein is released into the central nervous system to trigger downstream effects. This receptor is a common target of psychedelic drugs, including psilocybin mushrooms and LSD. Some psychedelic drugs are described as 5 HT2A agonists, meaning that they bind to this receptor with a high level of affinity. The receptor has also been studied by scientists who are interested in the relationship between this receptor and SSRIs, which are commonly used in the treatment of depression. Research has shown that patients with depression and a history of suicidal ideation have more 5 HT2A receptors than patients without these mental health issues, which could indicate that this receptor plays a role in mental health problems and treatment. The receptor is a common target of those seeking treatment for mental health issues, as it controls the flow of neurotransmitters responsible for mood regulation, such as serotonin.