Ayahuasca is a psychedelic drink or brew that is commonly used in South America that has spread all over the world. It is a common ceremonial spiritual medicine, particularly among cultures that have lived near the Amazon basin for centuries. It is made from a variety of ingredients, with the Banisteriopsis Caapi vine and the Psychotria Viridis shrub being some of the central ones. When put together, the MAOIs from the Baniesteriopsis activate the DMT in the Psychotria, leading to the psychedelic impact people feel. The substance plays a significant role in religious ceremonies, and it is often administered with the supervision of a shaman or a sitter who has experience watching these ceremonies unfold.