An anxiolytic is any substance that helps someone treat or reduce their anxiety. Some of the most common anxiolytics include benzodiazepine medications including Xanax, Klonopin, Valium, and Dalmane. Different anxiolytic medications have different degrees of onset. For example, Xanax kicks in quickly and leaves the body quickly, while Klonopin takes a longer time to work but also lasts longer in the body. Not every anxiolytic is a drug, as there are other ways people can treat their anxiety. The opposite of an anxiolytic is an anxiogenic, which is anything that increases anxiety.